Stice , IA A 1 AlleleTaqResponse to Food Is Moderated by Relation Between Obesity and Blunted Striatal
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منابع مشابه
Relation between obesity and blunted striatal response to food is moderated by TaqIA A1 allele.
The dorsal striatum plays a role in consummatory food reward, and striatal dopamine receptors are reduced in obese individuals, relative to lean individuals, which suggests that the striatum and dopaminergic signaling in the striatum may contribute to the development of obesity. Thus, we tested whether striatal activation in response to food intake is related to current and future increases in ...
متن کاملYouth at risk for obesity show greater activation of striatal and somatosensory regions to food.
Obese humans, compared with normal-weight humans, have less striatal D2 receptors and striatal response to food intake; weaker striatal response to food predicts weight gain for individuals at genetic risk for reduced dopamine (DA) signaling, consistent with the reward-deficit theory of obesity. Yet these may not be initial vulnerability factors, as overeating reduces D2 receptor density, D2 se...
متن کاملRelation between changes in neural responsivity and reductions in desire to eat high-calorie foods following gastric bypass surgery.
Reductions in reward-related (e.g. striatal) neural activation have been noted following obesity surgery. It has been speculated that these postoperative neural changes may be related to documented postoperative changes in food preferences; however, this relation has not been previously established. In this study, functional magnetic resonance imaging and rating scales were used to assess neura...
متن کاملWeight gain is associated with reduced striatal response to palatable food.
Consistent with the theory that individuals with hypofunctioning reward circuitry overeat to compensate for a reward deficit, obese versus lean humans have fewer striatal D2 receptors and show less striatal response to palatable food intake. Low striatal response to food intake predicts future weight gain in those at genetic risk for reduced signaling of dopamine-based reward circuitry. Yet ani...
متن کاملRelation of obesity to consummatory and anticipatory food reward.
This report reviews findings from studies that have investigated whether abnormalities in reward from food intake and anticipated food intake increase risk for obesity. Self-report and behavioral data suggest that obese relative to lean individuals show elevated anticipatory and consummatory food reward. Brain imaging studies suggest that obese relative to lean individuals show greater activati...
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تاریخ انتشار 2008